Best practice portal main page
Pharmacotherapy for methamphetamine withdrawal
Summary of the evidence
Different pharmacotherapy options for methamphetamine withdrawal were assessed in a systematic reivew with meta-analysis (Acheson et al., 2022, 9 RCTS of 6 medications, N= 242). Results found that:
- Amineptine may reduce discontinuation rates (RR 0.22, 95% confidence interval [CI] 0.07, 0.72, p = 0.01), and improve global state (MD -0.49, 95% CI -0.80, -0.17), compared with placebo, however, this medication is no longer approved.
- No other medications improved any domain when compared with placebo.
