Preventing fatal overdoses: a systematic review of the effectiveness of take-home naloxone

Drug overdose is one of the major causes of death among young people in Europe. This paper considers how naloxone — an effective antidote that can reverse opioid intoxication — combined with training in first aid for coping with an overdose for people who are not health professionals can help save lives. The evidence from the 21 studies analysed shows that educational and training interventions for peers and family members, complemented by take-home naloxone, may help decrease overdose-related mortality.